Ortho Biotic 100 is a high-dose probiotic delivering 100 billion active cultures for cases of gastrointestinal and immune distress. Each Ortho Biotic 100 capsule provides six proven probiotic strains chosen for their ability to survive the harsh GI environment to deliver superior results. Suggested Use: 1 capsule per day or as recommended by your health care professional. Guaranteed potency at expiration. No refrigeration required.